Primary immunodeficiency diseases are disorders in which part of the bodys immune system is missing or does not function properly these disorders can be divided into two groups those less common conditions with defects in the innate immune system a system of cells and mechanisms that defend the host from infection in a non specific manner. Innate immunity protects the host from infection but this response must be appropriately scaled and regulated to avoid devastating consequences for the host dysregulation of innate immunity can lead to chronic inflammation and diseases such as atherosclerosis arthritis autoimmunity and cancer tight regulation of these mechanisms is critical to prevent disease. However the answer posed by this question is critical to our understanding of the immune system and for comprehending the balance between protective immunity and autoimmunity this commentary tries to highlight a few important links between the innate and adaptive immune systems and how those may impinge on the course of autoimmune diseases. Harnessing the innate immune system the idea of using the immune system to help the body fight disease has been in existence for some time vaccines which allow the body to remember disease causing pathogens provide an excellent example there are many diseases though in which the desired outcome is not to enhance the immune system but to . Research at the centre for innate immunity and infectious diseases scientists at the centre for innate immunity and infectious diseases ciiid research the regulation of the innate immune response this early immune response determines how the body responds to infection or the presence of cancer cells providing immediate protection and sculpting the ensuing adaptive sustained immune
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